The research orientation of laboratory covers understanding of molecular basis of host-parasite relationship with the focus on infections caused by larval stages of cestodes and nematodes. With the aim of improving the current therapy of these diseases in animals and humans, we study, in the experimental settings, the alternative approaches based on combined therapy with drug and natural compounds. The rationale for this is to potentiate the efficacy of anthelmintic drugs and to alleviate their side effects in host´s as well as to reduce immunosuppression and pathological consequences of infections. The in vitro parasitic cestode model systems are employed in the search of novel compounds with antiparasitic or anti-inflammatory activities for therapeutical purposes.